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Chapter 22: Problem 10

Blood-brain barrier is injured in HIV-1 brain infection a. true b. false

Short Answer

Expert verified
b. false Evidence: The disruption of the Blood-brain barrier during HIV-1 brain infection has been widely documented in various research studies. One such study published in the Journal of Neuroscience states that "HIV infection compromises the integrity of the BBB, leading to abnormal permeability and the invasion of infected cells into the brain" (Dallasta et al., 1999). #Answer: a. true

Step by step solution

01

Understand the statement

Read and understand the statement: "Blood-brain barrier is injured in HIV-1 brain infection".
02

Research about Blood-brain barrier and HIV-1 brain infection

Research and gather information about the Blood-brain barrier and its role in the brain, as well as HIV-1 brain infection and its consequences. This will help in understanding the relationship between the two topics.
03

Identify the effects of HIV-1 brain infection on the Blood-brain barrier

From the information gathered in Step 2, identify the specific effects of HIV-1 brain infection on the Blood-brain barrier. Look for evidence that supports or refutes the statement.
04

Provide evidence for the answer

Numerous studies have shown that HIV-1 brain infection compromises the integrity of the Blood-brain barrier, allowing the passage of viral particles and infected cells into the brain, ultimately leading to neurological disorders. Therefore, the statement "Blood-brain barrier is injured in HIV-1 brain infection" is: a. true

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Most popular questions from this chapter

Peripheral anti-viral immune responses control in measure HIV-1 CNS infection a. true b. false

Productively infected cells in HIV-1 CNS infection are a. neurons b. endothelial cells c. oligodendrocytes d. macrophages/microglia e. all of the above

HIV-1 brain infection in post-HAART era is characterized by a. aggressive forms with severe HIVE and white matter injury b. "burnt-out" forms of HIVE c. more extensive \(\beta\)-amyloid \((A \beta)\) deposition d. more often occurrence of opportunistic infections e. \(a\) and \(d\) f. \(a, b\), and \(c\)

Pathology HIV-1 encephalitis (HIVE) is characterized by a. accumulation of neutrophils in the neuropil b. presence of multinucleated giant cells c. HIV-I inclusions in the nuclei d. decrease in number of astrocytes

Virus present in the brain tissues is a. CCR5-tropic b. CXCR4-tropic c. CX3CR-tropic d. none of the above e. all of the above
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