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Chapter 22: Problem 9

Peripheral anti-viral immune responses control in measure HIV-1 CNS infection a. true b. false

Short Answer

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Answer: True

Step by step solution

01

Understand the question

Read the statements carefully and understand the topic related to HIV-1 infection in the CNS and peripheral anti-viral immune responses.
02

Role of peripheral anti-viral immune responses

Learn about the role of peripheral anti-viral immune responses in controlling HIV-1 infection. These responses help to control viral replication and dissemination in the periphery, making it crucial to prevent the virus from reaching the CNS.
03

HIV-1 infection in the CNS

Understand how HIV-1 can infect the CNS. The CNS is susceptible to HIV-1 infection due to a compromised blood-brain barrier in specific regions. The infection in the CNS can lead to severe neurological complications, called HIV-associated neurocognitive disorders (HAND).
04

Assess the statement "Peripheral anti-viral immune responses control in measure HIV-1 CNS infection"

Consider whether peripheral anti-viral immune responses can control the extent of HIV-1 infection in the CNS. Peripheral anti-viral immune responses play a significant role in limiting viral replication and dissemination, which contributes to controlling the virus from reaching the CNS. However, once HIV-1 enters the CNS, local immune responses are mostly responsible for controlling the infection. So, peripheral anti-viral immune responses can control the HIV-1 infection in the CNS to some extent, but not completely.
05

Choose the correct answer

Based on the understanding of the role of peripheral anti-viral immune responses in controlling HIV-1 infection in the CNS, choose the correct answer between true (a) and false (b). The correct answer is: a. true

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Most popular questions from this chapter

Pathology HIV-1 encephalitis (HIVE) is characterized by a. accumulation of neutrophils in the neuropil b. presence of multinucleated giant cells c. HIV-I inclusions in the nuclei d. decrease in number of astrocytes

Productively infected cells in HIV-1 CNS infection are a. neurons b. endothelial cells c. oligodendrocytes d. macrophages/microglia e. all of the above

Virus present in the brain tissues is a. CCR5-tropic b. CXCR4-tropic c. CX3CR-tropic d. none of the above e. all of the above

Causes of neuronal injury in HIV-1 CNS infection are a. effects of viral proteins (gp41, gp 120) b. cytokines and chemokines c. glutamate d. anti-retroviral therapy e. all of the above f. a, b, and c only

Blood-brain barrier is injured in HIV-1 brain infection a. true b. false
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