The major adverse effect associated with the use of cidofovir is a. bone marrow suppression b. rashes c. arrhythmias d. headaches e. nephrotoxicity

Cidofovir is an antiviral drug used to treat viral infections, specifically cytomegalovirus (CMV) retinitis. It is a nucleotide analogue, which means it works by inhibiting viral DNA replication.

We will now go through each answer option and analyze whether it is the major adverse effect associated with Cidofovir use. a) Bone marrow suppression: Although some antiviral drugs may cause bone marrow suppression, it is not considered the major side effect associated with Cidofovir. b) Rashes: Skin reactions can be a side effect of many medications, but it is not the primary adverse effect related to Cidofovir. c) Arrhythmias: Cidofovir does not have a significant effect on the heart and is not known to cause arrhythmias as a major side effect. d) Headaches: Headaches can be a side effect of various medications, including Cidofovir. However, it is not considered the major adverse effect for this drug. e) Nephrotoxicity: Cidofovir is known to cause nephrotoxicity, which is damage to the kidneys as a result of the medication. It is considered the major adverse effect associated with Cidofovir use.

Based on the analysis of each answer option, the major adverse effect associated with the use of Cidofovir is nephrotoxicity (answer choice e).