Chapter 27: Problem 14
Studies of which disease have provided an increased understanding of the interactions between neurology and immunology? a. Mollaret's Meningitis b. Guillan Barre Syndrome c. poliomyelitis d. multiple sclerosis
Chapter 27: Problem 14
Studies of which disease have provided an increased understanding of the interactions between neurology and immunology? a. Mollaret's Meningitis b. Guillan Barre Syndrome c. poliomyelitis d. multiple sclerosis
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Get started for freeAssociation between viral infection and motor neuron disease is based upon cases of motor neuron disease due to retroviral infection (HIV, HTLV-1) and the presence of serum antibodies directed toward endogenous retroviral gene sequences in ALS patients. True/False
In vitro, motor neuron injury is induced by exposure to activated microglia. Which microglial constituents initiate such injury? 1\. kainite and \(\mathrm{IgG}\) 2\. mSOD1 and peroxynitrite 3\. glutamate and \(I g G\) 4\. peroxynitrite and glutamate a. \(1,2,3\) b. 1,3 c. 2,4 d. 4 only
Prostaglandins have a dual role in either promoting neuronal survival or apoptotic death. What factors may determine which role predominates in CNS injury or degeneration? 1\. Target cell and tissue environment, degree of cellular response to the inflammatory mediators, and profile of specific prostaglandin(s) 2\. Exposure to prostaglandin and cox-2 inhibitors, target cell and tissue environment, and profile of specific prostaglandins(s) a. both 1 and 2 b. neither 1 or 2 c. 1 d. 2
In CNS injury, the neuroprotective response of activated T cells is dependent upon early activation and differentiation of microglia into antigen presenting cells which release neurotrophic growth factors. True/False
A clinical diagnosis of ALS requires the demonstration of lower motor neuron involvement in which three areas? a. upper extremity limb, eye muscles, and paraspinous muscles b. lower extremity limb, eye muscles, and tongue c. upper extremity limb, tongue, paraspinous muscles d. lower extremity limb, upper extremity, eye muscles
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