Chapter 33: Problem 16
Characteristic of FTDP-17 is a. a phenotype that may be mistaken for \(\mathrm{AD}\) b. linkage to chromosome 17 c. abnormal Tau accumulation d. all of the above e. none of the above
Chapter 33: Problem 16
Characteristic of FTDP-17 is a. a phenotype that may be mistaken for \(\mathrm{AD}\) b. linkage to chromosome 17 c. abnormal Tau accumulation d. all of the above e. none of the above
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Get started for freeIn a genetic study, stratification may refer to a. unrecognized population sub-types due to recent admixture b. unrecognized population sub-types due to incorrect matching of cases and controls c. a method for presumably reducing genetic heterogeneity within a sample by narrowly defining the phenotype d. all of the above e. none of the above
Penetrance and expressivity refer to a. the proportion who get the disease and how the disease manifests respectively b. redundant terms c. how the disease manifests and the proportion who get the disease respectively d. all of the above e. none of the above
Huntington disease is an example of a dominantly inherited disease because a. two copies of the disease allele are needed to express the disease b. the disease locus is on the \(\mathrm{X}\) chromosome c. only one copy of the disease allele is needed to express the disease d. it exhibits classic anticipation e. it can only be inherited from an affected mother
Allelic genetic association analyses may find positive associations because the a. allele causes the disease b. allele is in strong linkage disequilibrium with the disease allele c. result is a false positive d. all of the above e. none of the above
All of the following have been candidates for a role in late-onset \(\mathbf{A D}\), but which is the most widely accepted and has the best supporting evidence for increasing susceptibility to \(\mathrm{AD}\) ? a. UBQLN1 b. \(\mathrm{APOE}\) c. GAPD d. \(\alpha-\mathrm{T}\) catenin e. VLDL-R
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