Chapter 33: Problem 6
Microsatellites a. are relatively highly polymorphic genetic markers b. can by amplified by polymerase chain reactions c. contain repeated elements d. all of the above e. none of the above
Chapter 33: Problem 6
Microsatellites a. are relatively highly polymorphic genetic markers b. can by amplified by polymerase chain reactions c. contain repeated elements d. all of the above e. none of the above
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Get started for freeCausative mutations in which of the following genes has been described in early-onset \(\mathrm{AD}\) ? a. amyloid precursor protein, presenilin-1, presenilin- 2 b. presenilin-1, amyloid precursor protein, apolipoprotein \(\mathrm{C}\) c. presenilin-1, presenilin-2, apolipoprotein \(C\) d. apolipoprotein C, presenilin-2, amyloid precursor protein e. huntingtin, presenilin-1, presenilin-2
All of the following have been candidates for a role in late-onset \(\mathbf{A D}\), but which is the most widely accepted and has the best supporting evidence for increasing susceptibility to \(\mathrm{AD}\) ? a. UBQLN1 b. \(\mathrm{APOE}\) c. GAPD d. \(\alpha-\mathrm{T}\) catenin e. VLDL-R
The genetics underlying multiple sclerosis are typical for a neurodegenerative disease in that a. concordance rates in monozygotic twins is higher than in dizygotic twins. b. linkage and association approaches have been used to identify likely candidates for a role in the disease c. there is an important environmental component to the disease d. all of the above e. none of the above
Heterogeneity within a disease may manifest as a. allelic heterogeneity, in which many variants of a single gene can cause the same disease b. locus heterogeneity, in which variants in many different genes may cause the same disease c. some of the difficulties underlying genetic studies of neurodegenerative diseases d. all of the above e. none of the above
Features of the apolipoprotein \(\mathbf{E}-4\) allele include a. increased susceptibility to late-onset \(\mathrm{AD}\). b. modification of age-at-onset in AD. c. a dose dependent effect on age-at-onset in \(\mathrm{AD}\). d. an association with other neurodegenerative diseases in addition to \(\mathrm{AD}\). e. all of the above.
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