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Chapter 33: Problem 8

Linkage analysis a. is limited by its exclusive use of restriction fragment length polymorphisms b. utilizes co-inheritance of a region of the genome with the disease locus to which it is "linked" c. has the advantage of always identifying causative mutations d. all of the above e. none of the above

Short Answer

Expert verified
Answer: Linkage analysis utilizes co-inheritance of a region of the genome with the disease locus to which it is "linked."

Step by step solution

01

Analyze Option A

Option A states that linkage analysis is limited by its exclusive use of restriction fragment length polymorphisms (RFLPs). This statement is false because, although RFLPs were initially widely used in linkage analysis, other types of genetic markers such as microsatellites, single nucleotide polymorphisms (SNPs), and copy number variations (CNVs) can also be used in linkage analysis.
02

Analyze Option B

Option B states that linkage analysis utilizes co-inheritance of a region of the genome with the disease locus to which it is "linked." This statement is true. Linkage analysis is used to map the location of a disease-causing gene by studying the inheritance of genetic markers in families with the disease. By identifying the genetic markers that are consistently co-inherited with the disease, researchers can pinpoint the location of the disease locus on a chromosome.
03

Analyze Option C

Option C states that linkage analysis has the advantage of always identifying causative mutations. This statement is false. While linkage analysis can help to narrow down the genomic region containing a disease-causing gene, it does not necessarily identify the specific causative mutation. Additional experiments, such as DNA sequencing or gene expression studies, might be required to pinpoint the exact mutation responsible for the disease.
04

Analyze Options D and E

Option D states that all of the statements (A, B, and C) are correct, and option E states that none of the statements are correct. Since we already determined that option B is true, option E is false. Additionally, since not all statements are true, option D is also false.
05

Conclusion

Based on the analysis of the given statements, the correct answer for this exercise is option B: Linkage analysis utilizes co-inheritance of a region of the genome with the disease locus to which it is "linked."

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Most popular questions from this chapter

Characteristic of FTDP-17 is a. a phenotype that may be mistaken for \(\mathrm{AD}\) b. linkage to chromosome 17 c. abnormal Tau accumulation d. all of the above e. none of the above

Allelic genetic association analyses may find positive associations because the a. allele causes the disease b. allele is in strong linkage disequilibrium with the disease allele c. result is a false positive d. all of the above e. none of the above

Features of the apolipoprotein \(\mathbf{E}-4\) allele include a. increased susceptibility to late-onset \(\mathrm{AD}\). b. modification of age-at-onset in AD. c. a dose dependent effect on age-at-onset in \(\mathrm{AD}\). d. an association with other neurodegenerative diseases in addition to \(\mathrm{AD}\). e. all of the above.

The genetics underlying multiple sclerosis are typical for a neurodegenerative disease in that a. concordance rates in monozygotic twins is higher than in dizygotic twins. b. linkage and association approaches have been used to identify likely candidates for a role in the disease c. there is an important environmental component to the disease d. all of the above e. none of the above

Heterogeneity within a disease may manifest as a. allelic heterogeneity, in which many variants of a single gene can cause the same disease b. locus heterogeneity, in which variants in many different genes may cause the same disease c. some of the difficulties underlying genetic studies of neurodegenerative diseases d. all of the above e. none of the above
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