1\. The NMDA hypothesis of schizophrenia refers to the following neurotransmitter disturbance: a. mesolimbic hyperactivity of dopamine b. tuberoinfundibular inhibition of prolactin release by dopamine c. hypofunction of the glutamatergic cortico-striatal pathway d. mesolimbic hyperactivity of glutamate e. all of the above

The N-Methyl-D-aspartate (NMDA) hypothesis of schizophrenia is a widely accepted theory linking glutamatergic abnormalities and the development of schizophrenia symptoms. According to this hypothesis, the dysfunction of the glutamate NMDA receptor, mainly related to the hypofunction of the glutamatergic cortico-striatal pathway, might be responsible for the development of schizophrenia symptoms.

The given options are: a. mesolimbic hyperactivity of dopamine b. tuberoinfundibular inhibition of prolactin release by dopamine c. hypofunction of the glutamatergic cortico-striatal pathway d. mesolimbic hyperactivity of glutamate e. all of the above

The options can be evaluated as follows: a. The mesolimbic hyperactivity of dopamine is related to the dopamine hypothesis of schizophrenia, which is a separate hypothesis from the NMDA hypothesis. b. Tuberoinfundibular inhibition of prolactin release by dopamine is more related to hormonal changes and not the NMDA hypothesis. c. Hypofunction of the glutamatergic cortico-striatal pathway is the primary focus of the NMDA hypothesis of schizophrenia. d. Mesolimbic hyperactivity of glutamate is not the disturbance found in the NMDA hypothesis but is instead related to the glutamate excitotoxicity hypothesis. e. All of the above option is not correct, as not all the options relate to the NMDA hypothesis of schizophrenia.

Based on the evaluation, the correct option is 'c. hypofunction of the glutamatergic cortico-striatal pathway' as it represents the neurotransmitter disturbance associated with the NMDA hypothesis of schizophrenia.