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Chapter 36: Problem 15

\- Administration of the COX-2 inhibitor celecoxib was shown to: a. induce exacerbation of psychotic symptoms in schizophrenia b. improve psychotic and especially cognitive in schizophrenia c. be more efficient in chronic schizophrenia than in the early stages d. enhance antidepressant therapy when added to a conventional antidepressant drug e. a and \(c\) f. b and \(\mathrm{d}\)

Short Answer

Expert verified
a) Induces exacerbation of psychotic symptoms in schizophrenia b) Improves psychotic and especially cognitive symptoms in schizophrenia c) Is more efficient in chronic schizophrenia than in the early stages d) Enhances antidepressant therapy when added to a conventional antidepressant drug e) a and c f) b and d Answer: f) b and d

Step by step solution

01

Analyze statement (a)

Determine if the COX-2 inhibitor celecoxib induces exacerbation of psychotic symptoms in schizophrenia: This statement is incorrect. Celecoxib, a COX-2 inhibitor, has been shown to have anti-inflammatory and neuroprotective effects, which may be beneficial for patients with schizophrenia.
02

Analyze statement (b)

Determine if the COX-2 inhibitor celecoxib improves psychotic and especially cognitive symptoms in schizophrenia: This statement is correct. Studies have shown that when used as an adjunctive treatment along with antipsychotics, celecoxib may improve psychotic symptoms and cognitive functioning in patients with schizophrenia.
03

Analyze statement (c)

Determine if the COX-2 inhibitor celecoxib is more efficient in chronic schizophrenia than in the early stages: There is no clear evidence available to support this statement, so it is considered incorrect.
04

Analyze statement (d)

Determine if the COX-2 inhibitor celecoxib enhances antidepressant therapy when added to a conventional antidepressant drug: This statement is correct. Some studies have shown that adding celecoxib to conventional antidepressant therapy may improve the effectiveness of the treatment, particularly in patients with treatment-resistant depression.
05

Analyze statement (e)

Determine if statements (a) and (c) are correct: As discussed in Steps 1 and 3, both statements are incorrect. Therefore, this option is incorrect.
06

Analyze statement (f)

Determine if statements (b) and (d) are correct: Based on the evaluations in Steps 2 and 4, both statements are correct. Therefore, this option is correct. The correct answer to this multiple-choice question is (f) b and d.

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Most popular questions from this chapter

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