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Chapter 41: Problem 16

Antiretroviral agents currently in use include inhibitors of reverse transcriptase, HIV protease, and fusion inhibitors. True/False

Short Answer

Expert verified
Answer: True.

Step by step solution

01

Understanding antiretroviral agents

Antiretroviral agents are medications used to treat HIV (Human Immunodeficiency Virus) infection. These medications work by inhibiting different stages of the HIV life cycle, thus preventing the virus from multiplying and reducing the amount of virus in the body. #Step 2: Investigating reverse transcriptase inhibitors#
02

Reverse transcriptase inhibitors

Reverse transcriptase inhibitors (RTIs) target the HIV reverse transcriptase enzyme, which is needed for the virus to replicate its genetic material. There are two main classes of RTIs: nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). These drugs are currently used as a part of antiretroviral therapy (ART) for HIV. #Step 3: Investigating HIV protease inhibitors#
03

HIV protease inhibitors

HIV protease inhibitors (PIs) target the HIV protease enzyme, which is responsible for cleaving the large viral polyprotein into individual proteins necessary for the assembly of new infectious viral particles. PIs are another crucial class of antiretroviral agents used in the treatment of HIV infection. #Step 4: Investigating fusion inhibitors#
04

Fusion inhibitors

Fusion inhibitors block the entry of HIV into host cells by inhibiting the fusion of the viral envelope with the host cell membrane. Enfuvirtide is a fusion inhibitor that is used as part of the antiretroviral therapy for patients who have developed resistance to other classes of antiretroviral drugs. #Step 5: Answering the True/False statement#
05

Conclusion

Based on the information from Steps 2-4, it is clear that the statement is True. Antiretroviral agents currently in use include inhibitors of reverse transcriptase, HIV protease, and fusion inhibitors.

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Most popular questions from this chapter

Currently there are six classes of antiretroviral agents available in the United States for clinical use: \- Nucleoside analogue reverse transcriptase inhibitors \- Nonnucleoside analogue reverse transcriptase inhibitors \- Protease inhibitors \- Entry inhibitors \- Tat inhibitors \- Nef inhibitors True/False

The clinical and laboratory features of HIV-associated dementia include all "except" which of the following? a. Psychomotor slowing b. History of HIV related disease c. Extrapyramidal symptoms d. Depression e. Reduced viral loads and serum beta 2 microglobulin

What aspects of clinical care have impacted the natural history of cognitive impairments in HIV infected individuals? a. The introduction of potent, combination anti-retroviral therapy b. The use of prophylactic medications against opportunistic infections c. Improved biomarkers for disease diagnosis d. One and two e. None of the above

HIV-associated dementia is also referred to as: a. HIV dementia b. AIDS Dementia Complex c. Subacute encephalopathy d. HIV-1-associated cognitive-motor complex e. All of the above

Which of the following protease inhibitors is the most powerful inhibitor of the \(\mathbf{P 4 5 0}\) enzyme? a. Atazanavir b. Fosamprenavir c. Indinavir d. Nelfinavir e. Ritonavir
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