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Chapter 41: Problem 17

Currently there are six classes of antiretroviral agents available in the United States for clinical use: \- Nucleoside analogue reverse transcriptase inhibitors \- Nonnucleoside analogue reverse transcriptase inhibitors \- Protease inhibitors \- Entry inhibitors \- Tat inhibitors \- Nef inhibitors True/False

Short Answer

Expert verified
Answer: False.

Step by step solution

01

Research and verify the classes of antiretroviral agents

To begin, we need to verify the information given in the exercise by conducting research and cross-referencing other sources. This is to ensure we have a complete understanding of the antiretroviral agents and their classifications. Step 2: Determine accuracy of the list
02

Determine accuracy of the list

After conducting research and verifying the information about antiretroviral agents, we can determine that the exercise statement is for the most part accurate. However, there is a slight discrepancy. The current six classes of antiretroviral agents are: 1. Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs) 2. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) 3. Protease Inhibitors (PIs) 4. Entry Inhibitors 5. Integrase Strand Transfer Inhibitors (INSTIs) 6. Post-Attachment Inhibitors Notice that Tat inhibitors and Nef inhibitors are not listed in the current six classes of antiretroviral agents. Step 3: Answer the true/false question
03

Answer the true/false question

As per our research, while the exercise statement lists the several widely-accepted classes of antiretroviral agents, it includes two classes (Tat inhibitors and Nef inhibitors) that are not a part of the widely-accepted list. So, the given statement in the exercise is False.

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Most popular questions from this chapter

A patient with HIV-associated dementia receiving antiretroviral therapy presents with a burning sensation in feet and hands, numbness and tingling in the feet, cramps in the legs, and absent ankle reflexes. What drug will you be the LEAST likely to blame on his/her new symptoms? a. Zidovudine b. Stavudine c. Didanosine d. Zalcitabine e. All of the above can cause the patient's symptoms

Which of the following nucleoside reverse transcriptase inhibitors has the best penetration into CSF? a. Zidovudine b. Didanosine c. Lamivudine d. Stavudine e. Abacavir

Which of the following drugs has been proven to be effective as adjuvant therapy for HIV associated dementia? a. Lexipafant b. Memantine c. Minocylcine d. Nimodipine e. None of the above f. All of the above

Which of the following class of drugs is not recommended for first line therapy in patients with HIVassociated dementia? a. Nucleoside reverse transcriptase inhibitors b. Non-nucleoside reverse transcriptase inhibitors c. Protease inhibitors d. Entry inhibitors e. All can be used as first line agents in the treatment of HAD

What is correct about the "Trojan Horse" model of HIV invasion into the CNS? a. Proposes that monocyte-macrophage carry progeny virions from blood to the brain inside cytoplasmic vacuoles and across the blood-brain barrier b. Requires an inflammatory response in the brain, which elicits a chemokine gradient c. After infiltrating the brain parenchyma, blood borne monocyte-macrophages also release additional chemokines and further attract additional inflammatory cells d. Does not require productive viral replication in brain microvascular endothelial cells e. All of the above
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