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Chapter 41: Problem 6
Which of the following nucleoside reverse transcriptase inhibitors has the best penetration into CSF? a. Zidovudine b. Didanosine c. Lamivudine d. Stavudine e. Abacavir
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In a busy clinical practice setting, the simplest neuropsychological test to diagnose HIV dementia is? a. Standard Mini-Mental Status test b. HIV-dementia scale c. Memorial Sloan Kettering Scale d. Halstead-Reitan Neuropsychological Battery e. San Diego HIV Neurobehavioral Research Center
Recent guidelines for starting anti-retroviral therapy recommend that patients with advanced disease, as manifested by the development of an AIDS-defining illness including HAD, or presence of severe symptoms such as unexplained fever, persistent diarrhea, or unexplained weight loss, should be started on ART if their \(\mathrm{CD}^{*} \mathrm{~T}\) cell count is \(<\mathbf{1 0 0}\). True/False
A patient with HIV-associated dementia was started on antiretroviral therapy two weeks ago. He complains of dizziness, insomnia, and vivid dreams. This reaction is most likely related to the use of: a. Zidovudine b. Tenofovir c. Lamivudine d. Efavirenz e. Nevirapine
What is not correct in regards to a diagnosis of HIVassociated dementia? a. HAD is a diagnosis of exclusion b. HIV does elicit an inflammatory response. This can be detected by mild lymphocytic pleocytosis, elevation of total protein, increase of total IgG, and/or the presence of oligoclonal bands c. HAD is always associated with a concurrent diagnosis of progressive multifocal leukoencephalopathy d. HAD almost always is associated with \(\mathrm{CD}^{+} \mathrm{T}\) cell counts of less than 600 e. The clinical manifestations of HAD include behavioral, cognitive, and/or motor abnormalities
Currently there are six classes of antiretroviral agents available in the United States for clinical use: \- Nucleoside analogue reverse transcriptase inhibitors \- Nonnucleoside analogue reverse transcriptase inhibitors \- Protease inhibitors \- Entry inhibitors \- Tat inhibitors \- Nef inhibitors True/False
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