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Chapter 41: Problem 8

Which of the following protease inhibitors is the most powerful inhibitor of the \(\mathbf{P 4 5 0}\) enzyme? a. Atazanavir b. Fosamprenavir c. Indinavir d. Nelfinavir e. Ritonavir

Short Answer

Expert verified
Answer: (e) Ritonavir

Step by step solution

01

Understand the terms

Protease inhibitors are a class of antiviral drugs that are used to treat HIV/AIDS and Hepatitis C. They work by inhibiting the activity of protease enzymes in the target virus, thus preventing the virus from replicating and spreading. The P450 enzyme is an important enzyme in the body involved in drug metabolism. Inhibition of P450 can lead to prolonged exposure to certain drugs, possibly leading to adverse effects.
02

Choose the most powerful inhibitor

Given the list of protease inhibitors (a) Atazanavir, (b) Fosamprenavir, (c) Indinavir, (d) Nelfinavir, and (e) Ritonavir, the most powerful inhibitor of the P450 enzyme is (e) Ritonavir.

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Most popular questions from this chapter

Contemporary treatment of HIV infection requires the use of two nucleoside reverse transcriptase inhibitors (NRTI) combined with either a non-nucleoside reverse transcriptase inhibitors or a protease inhibitor. Which of the following NRTI backbones will you prefer to use in a patient recently diagnosed with HIV-associated dementia: a. Zidovudine plus stavudine b. Zidovudine plus lamivudine c. Zalcitabine plus didanosine d. Zalcitabine plus lamivudine e. Didanosine plus tenofovir

Antiretroviral agents currently in use include inhibitors of reverse transcriptase, HIV protease, and fusion inhibitors. True/False

A patient with HIV-associated dementia was started on antiretroviral therapy two weeks ago. He complains of dizziness, insomnia, and vivid dreams. This reaction is most likely related to the use of: a. Zidovudine b. Tenofovir c. Lamivudine d. Efavirenz e. Nevirapine

Which of the following combinations will not be recommended for first line therapy in a patient with HIV associated dementia? a. Zidovudine plus lamivudine plus efavirenz b. Tenofovir plus emtricitabine plus lopinavir/ritonavir c. Tenofovir plus emtricitabine plus atazanavir/ritonavir d. Lamivudine plus abacavir plus fosamprenavir e. Zidovudine plus lamivudine plus abacavir

In a busy clinical practice setting, the simplest neuropsychological test to diagnose HIV dementia is? a. Standard Mini-Mental Status test b. HIV-dementia scale c. Memorial Sloan Kettering Scale d. Halstead-Reitan Neuropsychological Battery e. San Diego HIV Neurobehavioral Research Center
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