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Chapter 41: Problem 9

Which of the following drugs has been proven to be effective as adjuvant therapy for HIV associated dementia? a. Lexipafant b. Memantine c. Minocylcine d. Nimodipine e. None of the above f. All of the above

Short Answer

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a. Lexipafant b. Memantine c. Minocycline d. Nimodipine e. None of the above f. All of the above Answer: b. Memantine Explanation: Memantine is an NMDA receptor antagonist that has been proven effective in the treatment of Alzheimer's disease and other forms of dementia. It has also been demonstrated as a successful adjuvant therapy for HIV associated dementia by regulating the activity of NMDA receptor and diminishing the excitotoxicity caused by viral proteins. Among the given options, Memantine is the suitable adjuvant therapy for HIV associated dementia.

Step by step solution

01

Identifying the correct option

In this case, the correct answer is option b. Memantine.
02

Step 2:Explanation

Memantine is an NMDA receptor antagonist that has been proven effective in the treatment of Alzheimer's disease and other forms of dementia. It has also been demonstrated as a successful adjuvant therapy in HIV associated dementia by regulating the activity of NMDA receptor and diminishing the excitotoxicity caused by viral proteins. Therefore, option b. Memantine is the suitable adjuvant therapy for HIV associated dementia.
03

Discarding other options

a. Lexipafant - It is an anti-inflammatory drug that is not specifically proven effective for dementia treatment. c. Minocycline - While it has some neuroprotective effects, it has not been definitively proven for the treatment of HIV associated dementia. d. Nimodipine - It is a calcium channel blocker used to treat various cardiovascular disorders; its effectiveness in HIV associated dementia is not established. e. None of the above - This option is eliminated because Memantine is proven effective. f. All of the above - This option is eliminated because only Memantine is proven effective for treating HIV-associated dementia, among the options listed.

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Most popular questions from this chapter

Antiretroviral agents currently in use include inhibitors of reverse transcriptase, HIV protease, and fusion inhibitors. True/False

Which of the following drug classes are not currently licensed for the treatment of HIV disease? a. Nucleoside reverse transcriptase inhibitors b. Non-nucleoside reverse transcriptase inhibitors c. Protease inhibitors d. Entry inhibitors e. Inhibitors of viral maturation

Contemporary treatment of HIV infection requires the use of two nucleoside reverse transcriptase inhibitors (NRTI) combined with either a non-nucleoside reverse transcriptase inhibitors or a protease inhibitor. Which of the following NRTI backbones will you prefer to use in a patient recently diagnosed with HIV-associated dementia: a. Zidovudine plus stavudine b. Zidovudine plus lamivudine c. Zalcitabine plus didanosine d. Zalcitabine plus lamivudine e. Didanosine plus tenofovir

HIV-associated dementia is also referred to as: a. HIV dementia b. AIDS Dementia Complex c. Subacute encephalopathy d. HIV-1-associated cognitive-motor complex e. All of the above

The clinical and laboratory features of HIV-associated dementia include all "except" which of the following? a. Psychomotor slowing b. History of HIV related disease c. Extrapyramidal symptoms d. Depression e. Reduced viral loads and serum beta 2 microglobulin
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