Chapter 43: Problem 11

Which of the following is NOT a proposed mechanism to explain the anti- \(\mathbf{A} \boldsymbol{\beta}\) action of active immunization? a. Catalytic dissolution of amyloid plaques b. Microglial activation and amyloid degradation c. Clearance of amyloid through a peripheral sink d. Suppression of APP processing e. All of the above

Short Answer

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Answer: Suppression of APP processing

Step by step solution

Consider each option

Read each option and consider if it is a proposed mechanism to explain the anti-Aβ action of active immunization.

Option a: Catalytic dissolution of amyloid plaques

Catalytic dissolution of amyloid plaques is a proposed mechanism for the anti-Aβ action of active immunization. Antibodies that target Aβ plaques may help dissolve them, which would lead to reduced neurotoxicity.

Option b: Microglial activation and amyloid degradation

Microglial activation and amyloid degradation is another proposed mechanism for the anti-Aβ action of active immunization. Aβ antibodies may promote microglial phagocytosis and degradation of Aβ deposits, clearing them from the brain.

Option c: Clearance of amyloid through a peripheral sink

Clearance of amyloid through a peripheral sink is a suggested mechanism for the anti-Aβ action of active immunization. The presence of Aβ antibodies in the bloodstream might lead to a "sink" that can draw Aβ aggregates from the brain to be cleared through peripheral organs, such as the liver.

Option d: Suppression of APP processing

Suppression of APP processing is not a proposed mechanism for the anti-Aβ action of active immunization. Active immunization targets existing Aβ deposits, rather than reducing the production of new Aβ peptides. Suppressing APP processing would target the production of Aβ, which is not the aim of active immunization.

Answer and Explanation

The answer is Option d: Suppression of APP processing. This mechanism is NOT a proposed mechanism to explain the anti-Aβ action of active immunization, as it targets the production of new Aβ peptides instead of the existing Aβ deposits.

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Short Answer

Step by step solution

Consider each option

Option a: Catalytic dissolution of amyloid plaques

Option b: Microglial activation and amyloid degradation

Option c: Clearance of amyloid through a peripheral sink

Option d: Suppression of APP processing

Answer and Explanation

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