One molecular marker of nitric oxide modification of proteins is a. 8-hydroxyguanosine (8-OHG) b. 4-hydroxy-2-nonenal (HNE) c. 3-nitrotyrosine (NT) d. 8-hydroxy-2'-deoxyguanosine (8-OHdG)

Short Answer

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a. 8-hydroxyguanosine (8-OHG) b. 4-hydroxy-2-nonenal (HNE) c. 3-nitrotyrosine (NT) d. 8-hydroxy-2'-deoxyguanosine (8-OHdG) Answer: c. 3-nitrotyrosine (NT)

Step by step solution

01

Identify the Correct Option

To find the right answer, we need to determine which of the given options is associated with nitric oxide modification of proteins. a. 8-hydroxyguanosine (8-OHG) is an oxidatively modified nucleoside that is a marker of oxidative DNA and RNA damage. b. 4-hydroxy-2-nonenal (HNE) is a product of lipid peroxidation, which occurs due to oxidative stress. c. 3-nitrotyrosine (NT) is a protein modification that is formed by the reaction of tyrosine residues with the reactive nitrogen species (RNS) such as peroxynitrite. Nitric oxide contributes to the formation of RNS and this option is a direct molecular marker of nitric oxide modification of proteins. d. 8-hydroxy-2'-deoxyguanosine (8-OHdG) is an oxidatively damaged DNA marker that measures levels of oxidative stress in cells. The correct option is #tag_answer#c. 3-nitrotyrosine (NT)#tag_end_answer# as it is a molecular marker of nitric oxide modification of proteins.

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