Chapter 45: Problem 2

Lack of neuroprotection in thymectomized rats points to the role of naturally occurring regulatory \(\mathrm{CD}^{+} \mathrm{CD} 25^{+}\)T cells in endogenous neuroprotection YES/NO/UNRESOLVED

Short Answer

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Answer: YES

Step by step solution

Understand the terms

First, it's essential to understand the key terms in this statement. Thymectomized rats refer to rats that have had their thymus gland removed. The thymus gland is responsible for the maturation of T cells, which play a crucial role in the immune system. CD+ CD2 5+ T cells are a type of regulatory T cells (Tregs) which help modulate the immune system and prevent autoimmune reactions. Endogenous neuroprotection refers to the brain's natural ability to protect itself from damage and maintain cellular homeostasis.

Determine the role of T cells in neuroprotection

Next, we need to analyze the role regulatory T cells play in endogenous neuroprotection. Research shows that Tregs can cross the blood-brain barrier and provide neuroprotection by suppressing inflammation and aiding in immune responses.

Understand the consequence of thymectomy

Now, let's understand the consequence of thymectomy. The removal of the thymus gland has been found to cause a decrease in the number of Tregs in rats. With a reduced number of Tregs, the immune system may not function optimally, leading to a compromised ability for endogenous neuroprotection.

Draw conclusion

Based on the information, we can conclude that the lack of neuroprotection in thymectomized rats is likely due to the decrease in regulatory T cells. This supports the hypothesis that naturally occurring regulatory CD+ CD2 5+ T cells play an essential role in endogenous neuroprotection. As a result, the answer to the given exercise is: YES

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Lack of neuroprotection in thymectomized rats points to the role of naturally occurring regulatory \(\mathrm{CD}^{+} \mathrm{CD} 25^{+}\)T cells in endogenous neuroprotection YES/NO/UNRESOLVED

Short Answer

Step by step solution

Understand the terms

Determine the role of T cells in neuroprotection

Understand the consequence of thymectomy

Draw conclusion

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