Which of the following viral vector(s) delivers a genome that integrates in the transduced host cell genome? a. Adenovirus vectors b. HSV amplicon vectors c. Lentivirus vectors d. Replication-restricted HSV vectors e. Recombinant HSV vectors

It is necessary to know the key properties of the viral vectors listed in the exercise. For this exercise, the most important characteristic is their ability to integrate viral genes into the host's genome.

Now, let's examine each viral vector and determine if it integrates its genome into the host cell genome. a. Adenovirus vectors - They are a popular choice for gene therapy, but the adenovirus genome does not integrate into the host genome. Instead, it remains episomal, which means it exists separately from the host chromosome. b. HSV amplicon vectors - The Herpes Simplex Virus (HSV) amplicon vectors are based on HSV-1, a large DNA virus. The HSV amplicon vectors typically do not integrate into the host cell genome but instead form episomal circles in the nucleus. c. Lentivirus vectors - Lentivirus vectors are derived from retroviruses, which are RNA viruses known for their ability to integrate into the host cell genome. Therefore, lentivirus vectors do integrate into the host cell genome. d. Replication-restricted HSV vectors - These HSV vectors are engineered to have a limited replication ability in the host cell which reduces their cytotoxicity. However, they still maintain an episomal state in the host cell and do not integrate into the host genome. e. Recombinant HSV vectors - Although they are a modification of the HSV genome, recombinant HSV vectors, like other HSV-based vectors, do not integrate their viral genome into the host cell genome. They form episomal circles in the host nucleus.

Based on the analysis in step 2, the only viral vector that integrates its genome into the transduced host cell genome is the lentivirus vector. So, the correct answer is: c. Lentivirus vectors