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Chapter 5: Problem 7

All the following is true about anterior chamber immune associated deviation (ACAID) except: a. ACAID is an antigen-specific systemic immune response to eye-derived antigens. b. ACAID is an actively acquired and actively maintained manifestation of ocular immune privilege. c. In ACAID aqueous humor possesses immunomodulatory properties and inhibits all immune reactions. d. ACAID is a form of peripheral tolerance, unlike central tolerance, where clonal deletion and/or anergy occur within the thymus. e. Once induced, ACAID persists for a very long period of time.

Short Answer

Expert verified
Answer: In ACAID, aqueous humor possesses immunomodulatory properties and inhibits all immune reactions.

Step by step solution

01

Antigen-specific systemic immune response

ACAID is an antigen-specific systemic immune response to eye-derived antigens, so option a is correct.
02

Actively acquired and maintained manifestation

ACAID is an actively acquired and actively maintained manifestation of ocular immune privilege, meaning that it involves the eyes' ability to protect themselves from the immune system's harmful effects. Option b is correct as well. #Step 2: Identify the statements that may not be true about ACAID#
03

Inhibits all immune reactions

Option c states that in ACAID, aqueous humor possesses immunomodulatory properties and inhibits all immune reactions. However, this statement is not entirely accurate. ACAID does involve the immunomodulatory properties of the aqueous humor, but it doesn't inhibit all immune reactions completely. Instead, it modulates the immune response and reduces inflammation to protect the eye from damage.
04

Peripheral tolerance

Option d points out that ACAID is a form of peripheral tolerance, which is accurate. Unlike central tolerance, where clonal deletion and/or anergy occur within the thymus, peripheral tolerance in ACAID takes place outside the thymus.
05

Persists for a very long period

Option e states that once induced, ACAID persists for a very long period of time, which is true. ACAID can be a long-term mechanism to maintain the ocular immune privilege and protect the eye from inflammatory damage. #Step 3: Determine the incorrect statement#
06

Incorrect statement

Based on our assessment, option c is the statement that is NOT true about Anterior Chamber-Associated Immune Deviation (ACAID), as it claims that ACAID inhibits all immune reactions when it actually modulates the immune response to protect the eye from damage.

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