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Chapter 8: Problem 11

Oligodendrocytes progenitors are identified by \(\mathbf{A 2 B 5}\) antibody whereas pre-oligodendrocytes are identified by 04 antibody. a. True b. False

Short Answer

Expert verified
Answer: True

Step by step solution

01

Oligodendrocyte progenitors are precursor cells that give rise to mature oligodendrocytes, which produce myelin in the central nervous system. Pre-oligodendrocytes are intermediate cells in the development of oligodendrocytes. Antibodies are blood proteins that can specifically recognize and bind to target molecules, such as cell-surface markers. In this case, the A2B5 and 04 antibodies are used to identify oligodendrocyte progenitors and pre-oligodendrocytes, respectively. #Step 2: Verify the statement's correctness for oligodendrocyte progenitors#

It is true that oligodendrocyte progenitors are identified by the A2B5 antibody. This antibody recognizes the proteoglycan NG2 on the cell surface, which is a marker for oligodendrocyte progenitors. #Step 3: Verify the statement's correctness for pre-oligodendrocytes#
02

Pre-oligodendrocytes are indeed identified by the 04 antibody. The 04 antibody binds to galactocerebroside (GalC), a marker that is specifically expressed on the cell surface of pre-oligodendrocytes. #Step 4: Determine if the statement is true or false#

Both parts of the statement are correct: the A2B5 antibody identifies oligodendrocyte progenitors, and the 04 antibody identifies pre-oligodendrocytes. Therefore, the statement is: a. True

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