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Chapter 15: Problem 7

If no precautions are taken, blood that has been stored for some time becomes depleted in \(2,3-\mathrm{BPG}\). What happens if such blood is used in a transfusion?

Short Answer

Expert verified
If blood depleted in 2,3-BPG is used in a transfusion, the oxygen delivery to tissues is compromised due to increased hemoglobin oxygen affinity. This can lead to tissue hypoxia.

Step by step solution

01

Understanding 2,3-BPG role

2,3-BPG is an essential modulator of oxygen delivery in the body as it tends to lower the affinity of hemoglobin for oxygen, therefore promoting the release of oxygen from hemoglobin in tissues that need it.
02

2,3-BPG depletion effect on Hemoglobin

If the blood is depleted of 2,3-BPG due to prolonged storage, the affinity of hemoglobin for oxygen increases. That means the hemoglobin holds onto the oxygen and is less likely to release it to the tissues.
03

Transfusion Effect

When such blood is transfused into a patient, the oxygen carrying capacity of the blood is unaffected, but the oxygen delivery to tissues is compromised. This means that tissues especially those under anaerobic conditions or high oxygen demand, will not get the required amounts of oxygen, which can lead to tissue hypoxia.

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