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Chapter 3: Problem 13

Consider carbamoyl phosphate, a precursor in the biosynthesis of pyrimidines: Based on the discussion of high-energy phosphates in this chapter, would you expect carbamoyl phosphate to possess a high free energy of hydrolysis? Provide a chemical rationale for your answer.

Short Answer

Expert verified
Yes, carbamoyl phosphate is likely to possess a high free energy of hydrolysis. This is due to the high-energy phosphate bonds it contains, similar to those in ATP, which release a significant amount of energy when broken.

Step by step solution

01

Understanding carbamoyl phosphate

Carbamoyl phosphate is a molecule that contains two phosphate groups attached to a carbamoyl moiety (a molecule containing a carbonyl (C=O) and an amine (NH2) group). The structure of carbamoyl phosphate is such that it has high-energy phosphate bonds, similar to those in ATP (adenosine triphosphate).
02

Steps leading to hydrolysis

Hydrolysis is the process of breaking down a molecule by adding a water molecule. For carbamoyl phosphate, this would occur when the phosphate bonds are broken and a water molecule is added.
03

Predicting high energy of hydrolysis

High free energy of hydrolysis is commonly seen in molecules that contain high-energy phosphate bonds (such as ATP). The phosphate bonds in carbamoyl phosphate are similar to those in ATP, they are likely to also have high free energy when hydrolyzed. This is because breaking these phosphate bonds releases a significant amount of energy.

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