Chapter 30: Problem 10
Eukaryotic ribosomes are larger and more complex than prokaryotic ribosomes. What advantages and disadvantages might this greater ribosomal complexity bring to a eukaryotic cell?
Chapter 30: Problem 10
Eukaryotic ribosomes are larger and more complex than prokaryotic ribosomes. What advantages and disadvantages might this greater ribosomal complexity bring to a eukaryotic cell?
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Get started for freeWhy do you suppose eukaryotic protein synthesis is only \(10 \%\) as fast as prokaryotic protein synthesis?
How do prokaryotic cells determine whether a particular methionyltRNA \(^{\text {Met }}\) is intended to initiate protein synthesis or to deliver a Met residue for internal incorporation into a polypeptide chain? How do the Met codons for these two different purposes differ? How do eukaryotic cells handle these problems?
What is the Shine-Dalgarno sequence? What does it do? The efficiency of protein synthesis initiation may vary by as much as 100 -fold for different mRNAs. How might the Shine-Dalgarno sequence be responsible for this difference?
What ideas can you suggest to explain why ribosomes invariably exist as two- subunit structures, instead of a larger, single-subunit entity?
Review the evidence establishing that aminoacyl-tRNA synthetases bridge the information gap between amino acids and codons. Indicate the various levels of specificity possessed by aminoacyl-tRNA synthetases that are essential for high-fidelity translation of messenger RNA molecules.
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