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Chapter 31: Problem 1

(Integrates with Chapter 30 .) Human rhodanese \((33 \mathrm{kD})\) consists of 296 amino acid residues. Approximately how many ATP equivalents are consumed in the synthesis of the rhodanese polypeptide chain from its constituent amino acids and the folding of this chain into an active tertiary structure?

Short Answer

Expert verified
Approximately 592 ATP equivalents are consumed in the synthesis of the rhodanese polypeptide chain from its constituent amino acids.

Step by step solution

01

Understanding Amino Acids and ATP

Rhodanese consists of 296 amino acid residues. The activation of each amino acid during protein biosynthesis typically requires two ATP equivalents (considering ATP->ADP->AMP conversion).
02

Calculation of ATP for peptide bond formation

To form a protein, each amino acid molecule is activated once. Since the rhodanese protein has 296 amino acid residues, multiplying the number of residues (296) by the amount of ATP used to activate a single residue (2), we get 2 * 296 = 592 ATP equivalents are used in the formation of the peptide bonds of rhodanese.
03

Consideration of the ATP cost for tertiary structure formation

The question does not offer information on the ATP need for the tertiary structure of the rhodanese protein. However, this cost could be considered negligible compared to the ATP needed for peptide bond formation. Therefore, we can ignore this part in our calculation.

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Most popular questions from this chapter

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