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Chapter 31: Problem 18

The cross-talk between phosphorylation and ubiquitination in protein degradation processes is encapsulated in the concept of the "phosphodegron." What is a phosphodegron, and how does phosphorylation serve as a recognition signal for protein degradation? (A good reference on the phosphodegron and crosstalk between phosphorylation and ubiquitination is Hunter, \(\mathrm{T}\)., 2007 . The age of crosstalk: Phosphorylation, ubiquitination, and beyond. Molecular Cell \(28: 730-738 .\)

Short Answer

Expert verified
A phosphodegron is a motif in a protein that, when phosphorylated, is recognized and bound by E3 ubiquitin ligases. Phosphorylation serves as a recognition signal for protein degradation by modifying the protein into a phosphodegron. Upon recognition, the protein is ubiquitinated, marking it for degradation.

Step by step solution

01

Defining Phosphodegron

The first part of the response should define a phosphodegron. It is a motif in a protein that is recognized and bound by E3 ubiquitin ligases once it has been phosphorylated.
02

Explaining the role of Phosphorylation

Secondly, explain how phosphorylation works in the process. Phosphorylation adds a phosphate group to the protein, which changes the protein's structure into a phosphodegron. This new structure serves as a recognition signal for E3 ubiquitin ligases.
03

Describing the Protein Degradation Process

Finally, describe the sequence of events leading to protein degradation. Once the E3 ubiquitin ligases recognize and bind to the phosphorylated phosphodegron, the protein gets ubiquitinated. The transition of a protein into a phosphodegron, therefore, stimulates its degradation.

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