singer and Nicolson's fluid mosaic model of membrane structure presumed all of the following statements to be true EXCEPT: a. The phospholipid bilayer is a fluid matrix. b. Proteins can be anchored to the membrane by covalently linked lipid chains. c. Proteins can move laterally across a membrane. d. Membranes should be about 5 nm thick. e. Transverse motion of lipid molecules can occur occasionally.

Short Answer

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The statement not considered as per Singer and Nicolson's fluid mosaic model of membrane structure is 'd. Membranes should be about 5 nm thick.'

Step by step solution

01

Understand the fluid mosaic model

The fluid mosaic model explains the structure of cell membranes. The model describes the membrane as a highly mobile (fluid) and asymmetric (mosaic) system with proteins imbedded in or associated with the phospholipid bilayer.
02

Analyze the statements

Breakdown each statement to determine whether it aligns with the fluid mosaic model. 'a' states that the phospholipid bilayer is a fluid matrix, which is correct. 'b' mentions that proteins can be anchored to the membrane via covalently linked lipid chains, which is also true. 'c' posits that proteins can move laterally across a membrane, which complies too with the model. 'd' claims that the membranes should be about 5 nm thick, which is incorrect as per the fluid mosaic model, because it doesn't specifically dictate thickness.
03

Determine the incorrect option

The last option 'e' suggests that a transverse or flip-flop motion of lipid molecules can occur occasionally, which aligns with the model too. So, based on the analysis in Step 2 & 3, it becomes evident that option 'd' is the statement not claimed as per Singer and Nicolson's fluid mosaic model of membrane structure.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Cell Membrane Structure
The cell membrane, often described as the ‘skin’ of the cell, serves as a crucial barrier that separates the interior of the cell from its external environment. It is not simply a static layer, but a dynamic and complex structure that plays a key role in protecting the cell and facilitating communication and transport between the inside of the cell and its surroundings.

According to the fluid mosaic model, the cell membrane is composed of a phospholipid bilayer with various membrane proteins embedded within it. This arrangement allows the membrane to maintain its integrity while being flexible enough to enable the movement of substances in and out of the cell - a process essential for the cell's survival. The membrane's fluidity is a fundamental characteristic that permits the lateral movement of proteins and lipids, which is important for cell signaling and interaction.
Phospholipid Bilayer
The phospholipid bilayer forms the foundational framework of the cell membrane and is responsible for its semi-permeable nature. Each phospholipid molecule consists of a hydrophilic (water-attracting) 'head' and two hydrophobic (water-repellent) 'tails'. In an aqueous environment, these molecules naturally arrange themselves into a bilayer, with the heads facing the water on both the outside and inside of the cell, and the tails tucked away from the water.

This structure creates a selective barrier that allows only certain molecules to easily pass through. It is the continuous movement of the phospholipids that lend the membrane its fluid-like properties, essential for the diverse functions the membrane performs. Crucially, the structure and makeup of the phospholipid bilayer can also affect how the membrane interacts with different substances, influencing the overall functioning of the cell.
Membrane Proteins
Membrane proteins are integral to the functioning of the cell membrane, performing a variety of critical tasks. These proteins come in two main types: integral proteins that span the entire membrane and peripheral proteins that are bound to either the exterior or interior surface of the membrane.

These proteins can serve as channels or pumps controlling the passage of ions and molecules, act as receptors for signal transduction, or provide structural support. Some membrane proteins can move laterally, floating in the fluid lipid bilayer, allowing them to interact with various cellular components and signals. This mobility is vital for the cell's responsiveness to the environment. Additionally, the ability of some proteins to anchor to the membrane with covalently linked lipid chains demonstrates the versatility and dynamic nature of the cell membrane's protein network.

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Most popular questions from this chapter

In this chapter, we have examined coupled transport systems that rely on ATP hydrolysis, on primary gradients of \(\mathrm{Na}^{+}\) or \(\mathrm{H}^{+},\) and on phosphotransferase systems. Suppose you have just discovered an unusual strain of bacteria that transports rhamnose across its plasma membrane. Suggest experiments that would test whether it was linked to any of these other transport systems.

Proline residues are almost never found in short \(\alpha\) -helices; nearly all transmembrane \(\alpha\) -helices that contain proline are long ones (about \(20 \text { residues }) .\) Suggest a reason for this observation.

Discuss the effects on the lipid phase transition of pure dimyristoyl phosphatidylcholine vesicles of added (a) divalent cations, (b) cholesterol, (c) distearoyl phosphatidylserine, (d) dioleoyl phosphatidylcholine, and (e) integral membrane proteins.

(Integrates with Chapter 3 .) Fructose is present outside a cell at \(1 \mu M\) concentration. An active transport system in the plasma membrane transports fructose into this cell, using the free energy of ATP hydrolysis to drive fructose uptake. What is the highest intracellular concentration of fructose that this transport system can generate? Assume that one fructose is transported per ATP hydrolyzed; that ATP is hydrolyzed on the intracellular surface of the membrane; and that the concentrations of ATP, ADP, and \(P_{i}\) are \(3 \mathrm{m} M, 1 \mathrm{m} M,\) and \(0.5 \mathrm{m} M,\) respectively. \(T=298 \mathrm{K}\). (Hint: Refer to Chapter 3 to recall the effects of concentration on free energy of ATP hydrolysis.)

Phospholipid lateral motion in membranes is characterized by a diffusion coefficient of about \(1 \times 10^{-8} \mathrm{cm}^{2} /\) sec. The distance traveled in two dimensions (across the membrane) in a given time is \(r=(4 D t)^{1 / 2},\) where \(r\) is the distance traveled in centimeters, \(D\) is the diffusion coefficient, and \(t\) is the time during which diffusion occurs. Calculate the distance traveled by a phospholipid across a bilayer in 10 msec (milliseconds).

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