Chapter 29: Q35P (page 1192)
What is the structure of each amino acid at its isoelectric point: (a) alanine (b) methionine; (c)aspartic acid; (d) lysine?
Chapter 29: Q35P (page 1192)
What is the structure of each amino acid at its isoelectric point: (a) alanine (b) methionine; (c)aspartic acid; (d) lysine?
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(a) Valine;
(b) Leucine;
(c) Phenylalanine.
Histidine is classified as a basic amino acid because one of the N atoms in its five-membered ring is readily protonated by acid. Which N atom in histidine is protonated and why?
Devise a synthesis of each peptide from amino acid starting materials:
(a) Leu–Val; (b) Ala–Ile–Gly.
Draw the amino acids and peptide fragments formed when the decapeptide A-P-F-L-K-W-S-G-R-G is treated with each reagent or enzyme: (a) chymotrypsin; (b) trypsin; (c) carboxypeptidase; (d)
Use the given experimental data to deduce the sequence of an octapeptide that contains the following amino acids: Ala, Gly (2 equiv), His (2 equiv), Ile, Leu and Phe. Edman degradation cleaves Gly from the octapeptide, and carboxypeptidase forms Leu and a heptapeptide. Partial hydrolysis forms the following fragments: Ile-His-Leu, Gly, Gly-Ala-Phe-His, and Phe-His-Ile.
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