Chapter 18: 35 P (page 721)
What is the major product formed by an intramolecular Friedel–Crafts acylation of the following compound?

Short Answer
The major product formed is as follows:

Chapter 18: 35 P (page 721)
What is the major product formed by an intramolecular Friedel–Crafts acylation of the following compound?

The major product formed is as follows:

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Question: Devise a stepwise mechanism for the following reaction. The reaction does not take place by direct electrophilic aromatic substitution at C2 . (Hint: The mechanism begins with addition of an electrophile at C3.)

Draw the product of each reaction.

Draw the products of each reaction.


Draw the products of each reaction.

Question: Devise a synthesis of optically active (S)-fluoxetine (trade name Prozac) from the given starting materials and any other needed reagents.

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