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Chapter 7: PROBLEM 7.36 (page 286)

Question: Nicotine, a toxic and addictive component of tobacco, is synthesized from A using SAM. Write out the reaction that converts A into nicotine.

Short Answer

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Step by step solution

01

Substitution Reactions

The reactions in which a group/atom is substituted/replaced by another are referred to as substitution reactions.

02

SN2 (substitution nucleophilic bimolecular) Reactions

The substitution reactions in which the addition of a nucleophile and the elimination of the leaving group occur simultaneously are referred to as the substitution nucleophilic bimolecular (SN2) reaction.

03

Synthesis of nicotine

The reaction that converts A to nicotine is provided below.

Conversion of A to nicotine

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Most popular questions from this chapter

Question: When trichloride J is treated with CH3OH , nucleophilic substitution forms the dihalide K. Draw a mechanism for this reaction and explain why one Cl is much more reactive than the other two Cl’s so that a single substitution product is formed.

Question: Which of the following molecules contain a good leaving group?

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b.

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Question: Give the IUPAC name for each compound.

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b.

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Question: When (R)-6-bromo-2,6-dimethylnonane is dissolved in , nucleophilic substitution yields an optically inactive solution. When the isomeric halide (R)-2-bromo-2,5- dimethylnonane is dissolved in under the same conditions, nucleophilic substitution forms an optically active solution. Draw the products formed in each reaction, and explain why the difference in optical activity is observed.

Question: What neutral nucleophile is needed to convert dihalide A to ticlopidine, an antiplatelet drug used to reduce the risk of strokes?
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