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Chapter 29: Q62. (page 1196)

Write out the steps for the synthesis of each peptide using the Merrifield method:

  1. Ala-Leu-Phe-Phe; (b) Phe-Gly-Ala-Ile.

Short Answer

Expert verified

Merrifield method is a method developed by Bruce Merrifield, and it requires connecting the C-terminus of the peptide chain with a solid in polymeric form.In this method, the product is purified at every step to avoid unwanted cross-reactions.

Step by step solution

01

Merrifield Method

Merrifield method is a method developed by Bruce Merrifield, and it requires connecting the C-terminus of the peptide chain with a solid in polymeric form.In this method, the product is purified at every step to avoid unwanted cross-reactions.

02

Synthesis of Ala-Leu-Phe-Phe

First of all, make all the Fmoc derivatives for amino acids. The steps for the synthesis of Ala-Leu-Phe-Phe are shown as

03

Synthesis of Phe-Gly-Ala-Ile

Firstly, make all the Fmoc derivatives for amino acids. The steps for the synthesis of Phe-Gly-Ala-Ile are shown as,

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Most popular questions from this chapter

What alkene is needed to synthesize each amino acid by an enantioselective hydrogenation reaction using and :

(a) Alanine;

(b) Leucine;

(c) Glutamine?

Write out the steps for the synthesis of each peptide using the Merrifield method:

(a)Ala-Leu-Phe-Phe;

(b) Phe-Gly-Ala-Ile.

Tryptophan is not classified as a basic amino acid even though it has a heterocycle containing a nitrogen atom. Why is the N atom in the five-membered ring of tryptophan not readily protonated by acid?

Devise a synthesis of each amino acid from acetaldehyde:

(a) Glycine;

(b) Alanine.

Name each peptide using both the one-letter and the three-letter abbreviations for the names of the component amino acids.

a.

b.
See all solutions

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