Chapter 29: Q65. (page 1197)
Draw the mechanism for the reaction that removes an Fmoc group from an amino acid under the following conditions:
Chapter 29: Q65. (page 1197)
Draw the mechanism for the reaction that removes an Fmoc group from an amino acid under the following conditions:
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Get started for freeWrite out the steps for the synthesis of each peptide using the Merrifield method:
As shown in Mechanism 29.2, the final steps in the Edman degradation result in rearrangement of a thiazolinone to an N-phenylthiohydantoin. Draw a stepwise mechanism for this acid-catalyzed reaction.
Consider the decapeptide angiotensin I.
The larger polypeptide is angiotensin II, a hormone that narrows blood vessels and increases blood pressure. Give the amino acid sequence of angiotensin II using threeletter abbreviations. ACE inhibitors are drugs that lower blood pressure by inhibiting the ACE enzyme (Problem 5.15).
L-thyroxine, a thyroid hormone and oral medication used to treat thyroid hormone deficiency, is an amino acid that does not exist in proteins. Draw the zwitterionic form of L-thyroxine.
The fibroin proteins found in silk fibers consist of large regions of β-pleated sheets stacked one on top of another. (a) Explain why having a glycine at every other residue allows the β-pleated sheets to stack on top of each other. (b) Why are silk fibers insoluble in water?
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