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Chapter 26: Q 25. (page 1069)

What product is formed in the Suzuki coupling of A and B? This reaction was a key step in the synthesis of losartan, a drug used to treat hypertension.

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01

Suzuki reaction

Numerous coupling reactions are present, and Suzuki reactions are categorized as coupling reactions. Suzuki reactions are conducted with the help of palladium catalysts.

02

Lozartan

Another name for the medication Lozartan is Cozaar. It is consumed through the mouth and can cure several conditions such as blood pressure, heart failure, etc.

03

Product formed in the Suzuki coupling of A and B

Compound A, an organic halide, reacts with compound B, an organoborane in the presence of PdOAc2and NaOH, to give rise to the stereospecific product. The reaction can be given as follows.

Suzuki coupling of A and B

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Most popular questions from this chapter

Suzuki coupling of aryl iodide A and vinyl borane B affords compound C, which is converted to D in the presence of aqueous acid. Identify compounds C and D and draw a stepwise mechanism for the conversion of C to D.

What products are formed when cis-pent-2-ene undergoes metathesis? Use this reaction to explain why metathesis of a 1, 2-disubstituted alkene (RCH=CHR') is generally not a practical method for alkene synthesis?

Draw the product of each coupling reaction.

a.

b.

c.

d.

Although diazomethane ( CH2N2) is often not a useful reagent for preparing cyclopropanes,other diazo compounds give good yields of more complex cyclopropanes. Draw a stepwisemechanism for the conversion of diazo compound A to B, an intermediate in the synthesis ofsirenin, the sperm attractant produced by the female gametes of the water mold Allomyces.

Draw the products formed in each reaction.
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