Chapter 26: Q26P (page 1049)
Identify X, an intermediate that was converted to eletriptan (trade name Relpax), a drug used to treat migraines.
Chapter 26: Q26P (page 1049)
Identify X, an intermediate that was converted to eletriptan (trade name Relpax), a drug used to treat migraines.
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Get started for freeDraw the products (including stereoisomers) formed in each reaction.
Devise a synthesis of diene A from (Z)-2-bromostyrene as the only organic starting material. Use a Suzuki reaction in one step of the synthesis.
What reagents are needed to carry out transformations [1]–[3] in the synthesis of aldehyde A? A can be converted to the antitumor agent maytansine in several steps.
What product is formed by ring-closing metathesis of each compound?
a.
b.
Bi-aryls, compounds containing two aromatic rings joined by a C-C bond, can often be efficiently made by two different Suzuki couplings; that is, either aromatic ring can be used to form the organoborane needed for coupling. In some cases, however, only one route is possible. With this in mind, synthesize each of the following bi-aryls using benzene as the starting material for each aromatic ring. When more than one route is possible, draw both of them. You may use any required organic or inorganic reagents.
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