Chapter 5: Q.6 (page 182)
Locate the stereogenic centers in each molecule. Compounds may have one or more stereogenic centers.
b.
c.
d.
e.
f.
Short Answer
a.
b.
c.
d.
e.
f.
Chapter 5: Q.6 (page 182)
Locate the stereogenic centers in each molecule. Compounds may have one or more stereogenic centers.
b.
c.
d.
e.
f.
a.
b.
c.
d.
e.
f.
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Get started for freeThe facts in Section 5.4A can be used to locate stereogenic centers in any molecule, no matter how complicated. Always look for carbons surrounded by four different groups. With this in mind, locate the four stereogenic centers in aliskiren, a drug introduced in 2007 for the treatment of hypertension.
a. Locate the stereogenic centres in the ball-and-stick model of lisinopril, a drug used to treat high blood pressure.
b. Label each stereogenic centre as R or S.
Pure MSG, a common flavor enhancer, exhibits a specific rotation of +24. (a) Calculate the ee of a solution whose is +10. (b) If the ee of a solution of MSG is 80%, what is for this solution?
MSG
monosodium glutamate
Draw the structures for each compound.
A limited number of chiral compounds having no stereogenic centers exist. For example, although A is achiral, constitutional isomer B is chiral. Make models and explain this observation. Compounds containing two double bonds that share a single carbon atom are called allenes. Locate the allene in the antibiotic mycomycin and decide whether mycomycin is chiral or achiral.
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