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Chapter 19: Q18P (page 1002)

What would happen in the synthesis of sulfanilamide if the amino group were not protected as an amide in the chlorosulfonation step?

Short Answer

Expert verified

In the synthesis of sulfanilamide the amino group is protected in the chlorosulfonation step. As the amine group can acts as nuclephile to attack the chlorosulfonic acid and remove chlorine. That is the why the amine group is being protected.

Step by step solution

01

Cause and result if we do not protect the amine group

In the synthesis of sulfanilamide the amino group is protected in the chlorosulfonation step. As the amine group can acts as nuclephile to attack the chlorosulfonic acid and remove chlorine. That is the why the amine group is being protected.

Step 2: Preparation oof the sulfonamide from protected amine.

At first the amine group is protected and then chlorosulfonic acid is added to give para sulfonyl chloride product. The steps of this conversion is given below.

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