What dipeptides would be formed by heating a mixture of valine and N- protected leucine?

Short Answer

Expert verified

The answer is:

Leu-Val

Val-Val

Step by step solution

01

Step-by-Step Solution Step 1: Dipeptides

The dipeptides are peptides comprised of two amino acids. The peptides are the amino acid chains interconnected by the peptide bond. The RCONHR’ bond is called the peptide bond. The peptides composed of two, three, four, and five amino acids are dipeptide, tripeptide, tetrapeptide, and pentapeptide, respectively.

02

Explanations

The Leu-Val and Val-Val are formed. This is because the amino group of leucine is protected, so leucine cannot react with the carboxyl group, and hence leucine cannot be a C-terminal amino acid. The amino group of valine can react equally with the carboxyl group of other molecules and with that of leucine.

The dipeptides formed are given below.

Leu-Val

Val-Val

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Most popular questions from this chapter

After the polypeptide shown below was treated with maleic anhydride, it was hydrolyzed by trypsin. (After a polypeptide is treated with maleic anhydride,

trypsin will cleave the polypeptide only on the C-side of arginine.)

Gly-Ala-Asp-Ala-Leu-Pro-Gly-Ile-Leu-Val-Arg-Asp-Val-Gly-Lys-Val-Glu-Val-Phe-Glu-Ala-Gly-

Arg-Ala-Glu-Phe-Lys-Glu-Pro-Arg-Leu-Val-Met-Lys-Val-Glu-Gly-Arg-Pro-Val-Gly-Ala-Gly-Leu-Trp

a. After a polypeptide is treated with maleic anhydride, why does trypsin no longer cleave it on the C-side of lysine?

b. How many fragments are obtained from the polypeptide?

c. In what order will the fragments be eluted from an anion-exchange column using a buffer of pH = 5?

Explain the difference in the \({\bf{p}}{{\bf{K}}_{\bf{a}}}\) values of the carboxyl groups of alanine, serine, and cysteine.

Show the peptides that would result from cleavage by the indicated reagent:

a. Val-Arg-Gly-Met-Arg-Ala-Ser by carboxypeptidase A

b. Ser-Phe-Lys-Met-Pro-Ser-Ala-Asp by cyanogen bromide

c. Arg-Ser-Pro-Lys-Lys-Ser-Glu-Gly by trypsin

A mixture of amino acids that do not separate sufficiently when a single technique is used can often be separated by two-dimensional chromatography.In this technique, the mixture of amino acids is applied to a piece of filter paper and separated by chromatographic techniques. The paper is then rotated90°,and the amino acids are further separated by electrophoresis, producing a type of chromatogram called a fingerprint.Identify the spots in the fingerprint obtainedfrom a mixture of Ser, Glu, Leu, His, Met, and Thr.

What alkyl halide is used in the acetamidomalonic ester synthesis to prepare a. lysine? b. phenylalanine?

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