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Chapter 18: Q105P (page 923)

Show how lidocain, one of the most widely used injectable anaesthetics, can be prepared from benzene and compounds containing no more than four carbons.

Iidocain

Short Answer

Expert verified

The answer is,

Reaction

Step by step solution

01

Benzene

Benzene can be used for the synthesis of organic compounds containing large substituents. The compounds like Novocain and lidocain can be synthesised from benzene using a series of chemical reactions using different reagents.

02

Explanation

The reaction for the synthesis of lidocain is as given below.

Reaction

The Friedel- Crafts reaction can be done on a ring with a sulfonic acid group, because its deactivation is offset by the activating amide group. The sulfonic acid group is put on the ring to block the para position, forcing the methyl groups to go to the ortho positions.

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Most popular questions from this chapter

Write the sequence of steps required for the conversion of benzene into benzenediazonium chloride.

Benzene underwent a Friedel–Crafts acylation followed by a Wolff–Kishner reduction. The product gave the following 1H NMR spectrum. What acylchloride was used in the Friedel–Crafts acylation?

Diazomethane can be used to convert a carboxylic acid to a methyl ester. Propose a mechanism for this reaction.

Show how the following compounds can be prepared from benzene:

a. Ketoprofen, like ibuprofen, is an anti-inflammatory analgesic. How can ketoprofen be synthesised from the given starting material?

Ketoprofen

b. ketoprofen and ibuprofen both have a propanoic acid substituent. Explain why the identical subunits are synthesised in different ways.
See all solutions

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