Draw the structure for each of the following:

a. dCDP

b. dTTP

c. dUMP

d. UDP

e. guanosine triphosphate

f. adenosine 5’-monophosphate

A nucleotide is a nucleoside with an OH group of the sugar bonded in an ester linkage to phosphoric acid. The nucleotides of RNA are more precisely called ribonucleotides, and those of DNA are called deoxyribonucleotides.

a)

From the name-deoxycytidine--diphosphate (dCDP), it is clear that anomeric carbon of furanose ring is bonded to pyrimidine ring of cytosine at N-1, and cytidine nucleoside has two phosphate groups attached. Thus, the structure of -deoxycytidine--diphosphate (dCDP) is represented as follows:

Structure of dCDP (a)

b)

From the name -deoxythimidine--triphosphate (dTTP), it is clear that anomeric carbon of furanose ring is bonded to the pyrimidine ring of thymine at N-1 and thymidine nucleoside has three phosphate groups attached. Thus, the structure of -deoxythymidine--triphosphate (dTTP) is represented as:

Structure of dTTP (b)

c)

From the name uridine--phosphate (dUMP), it is clear that anomeric carbon of furanose ring is bonded to pyrimidine ring of uracil at N-1 and uridine nucleoside has one phosphate group attached. Thus, the structure of uridine--phosphate (dUMP) is shown as follows:

Structure of dUMP (c)

d)

From the name uridine--diphosphate (dUDP), it is clear that anomeric carbon of furanose ring is bonded to pyrimidine ring of uracil at N-1 and uridine nucleoside has two phosphate groups attached. Thus, the structure of uridine--diphosphate (dUDP) is as shown:

Structure of dUDP (d)

e)

From the name guanosine triphosphate (dGTP), it is clear that anomeric carbon of furanose ring is bonded to purine ring of guanine at N-9 and guanosine nucleoside has three phosphate group attached. Thus, the structure of guanosine triphosphate is as shown:

Structure of dGTP (e)

f)

From the name adenosine--monophosphate (AMP), it is clear that anomeric carbon of furanose ring is bonded to purine ring of adenine at N-9 and adenosine nucleoside has one phosphate groups attached. Thus, the structure of adenosine--monophosphate (AMP) is as shown: