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Chapter 23: Q21P (page 1092)

Question: How do the structures of tetrahydrofolate and aminopterin differ?

Short Answer

Expert verified

These structures differ by an amino group in tetrahydrofolate and keto group in aminopterin

Step by step solution

01

Tetrahydrofolate and aminopterin drugs

Aminopterin is an anticancer drug, an example of competitive inhibitor. Tetrahydrofolate is the coenzyme derived from reduction of two double bonds from folic acid.The coenzyme is used with enzymes that require transfer of a group containing one carbon to their substrates.

02

Difference in the structure of given drugs

The only difference between two drugs is there is an amino group in 4th position of tetrahydrofolate whereas in aminopterin 4th position is occupied by keto group.


Thus, the structure difference in between tetrahydrofolate and aminopterin is shown above.

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Most popular questions from this chapter

Question: Name the coenzymes that

a. allow electrons to be delocalized.

b. are oxidizing agents.

c. provide a strong base.

d.donate one-carbon groups

Explain why the hydrogens of the C-8 methyl group are more acidic than those of the C-7 methyl group.

Question:Draw the products of the following reaction, where T is tritium:

\(\alpha \)-Keto acids other than \(\alpha \) -ketoglutarate can accept the amino group from pyridoxamine in enzyme catalyzed transamination reactions. What amino acids are formed when the following a-keto acids accept the amino group?

Which compound is more easily decarboxylated?
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