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Chapter 23: Q21P (page 1092)

Question: How do the structures of tetrahydrofolate and aminopterin differ?

Short Answer

Expert verified

These structures differ by an amino group in tetrahydrofolate and keto group in aminopterin

Step by step solution

01

Tetrahydrofolate and aminopterin drugs

Aminopterin is an anticancer drug, an example of competitive inhibitor. Tetrahydrofolate is the coenzyme derived from reduction of two double bonds from folic acid.The coenzyme is used with enzymes that require transfer of a group containing one carbon to their substrates.

02

Difference in the structure of given drugs

The only difference between two drugs is there is an amino group in 4th position of tetrahydrofolate whereas in aminopterin 4th position is occupied by keto group.


Thus, the structure difference in between tetrahydrofolate and aminopterin is shown above.

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Most popular questions from this chapter

Question:Thiols such as ethanethiol and propanethiol can be used to reduce vitamin K epoxide to vitamin KH2, but they react much more slowly than dihydrolipoate. Explain why this is so.

What are the products of the following reaction?

Question:Draw the products of the following reaction, where T is tritium:

\(\alpha \)-Keto acids other than \(\alpha \) -ketoglutarate can accept the amino group from pyridoxamine in enzyme catalyzed transamination reactions. What amino acids are formed when the following a-keto acids accept the amino group?

Question:Five coenzymes are required by -ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts -ketoglutarate to succinyl-CoA.

a. Identify the coenzymes.

b.Propose a mechanism for the reaction.
See all solutions

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