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Chapter 23: Q22P (page 1092)

Question: What is the source of the methyl group in thymidine?

Short Answer

Expert verified

The primary source of methyl group in thymidine is from N5, N10-methylene-THF. Tetrahydrofolate is a co-enzyme required by enzyme catalyzed reactions.

Step by step solution

01

The structure of N5, N10-methylene-THF

It is one of the co-enzyme of tetrahydrofolate transfers its methylene group to their substrates.

02

Source of methyl group in thymidine

Thymidine is derived by the addition of hydride ion from N5, N10-methylene-THF to uracil base. Thus,methyl group in thymidine is comes from the coenzyme N5, N10-methylene-THF. The methylene group of N5, N10-methylene-THF comes from the CH2OH group of serine by means of a PLP catalyzed bond cleavage.

Thus, source of methylene group in thymidine base is explained.

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