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Chapter 23: Q8P (page 1076)

Draw structures that show the similarity between the decarboxylation of the pyruvate–TPP intermediate and the decarboxylation of a \(\beta \)-keto acid.

Short Answer

Expert verified

Pyruvate decarboxylation is a reaction where a carboxylate group is removed and hydrogen is added. This reaction converts pyruvate to acetyl CoA.

Step by step solution

01

Pyruvate decarboxylation

Pyruvate decarboxylation is a reaction where a carboxylate group is removed and hydrogen is added. This reaction converts pyruvate to acetyl CoA.

02

Beta- keto acid decarboxylation

During this reaction an enol intermediate is formed by proton transfer from the carboxylic acid group to the carbonyl oxygen atom of the ketone. So ketone from in this reaction.

03

Structures showing similarity in decarboxylation of pyruvate and beta- keto acid

In the mechanism of the two above reactions the structures showing similarity are:

Here it can be seen that the electron delocalization is occurring in same manner.

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