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Chapter 28: Q28-19E (page 963)

One of the steps in the metabolic degradation of guanine in hydrolysis to give xanthine. Propose a mechanism.

Short Answer

Expert verified

The mechanism for the hydrolysis of guanine is

Step by step solution

01

Definition of mechanism 

The sequence of elementary steps by which a chemical reaction occurs is defined as a mechanism.

02

Explanations

The hydrolysis of guanine occurs by the catalytic guanine deaminase and occurs when water reacts according to the nucleophilic addition reaction. Water gets added according to the nucleophilic addition reaction to the CN bond.

This is followed by the removal of ammonia by a substitution reaction.

The hydrolysis of guanine gives rise to xanthine

The mechanism for the hydrolysis of guanine is,

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Most popular questions from this chapter

Question: The codon UAA stops protein synthesis. Why does the sequence UAA in the following stretch of mRNA not cause any problems?

-GCA-UUC-GAG-GUA-ACG-CCC-

Question: What amino acid sequence is coded for by the following DNA coding strand (sense strand)? (5') CTT-CGA-CCA-GAC-AGC-TTT (3’)

Draw the structure of cyclic adenosine monophosphate (CAMP), a messenger involved in the regulation of glucose production in the body. Cyclic AMP has a phosphate ring connecting the 3'- and 5'-hydroxylgroups in adenosine.

Identify the following nucleotide, and tell how it is used.

Question: Which of the following base sequences would most likely be recognized by a restriction endonuclease? Explain

  1. GAATTC
  2. GATTACA
  3. CTCGAG
See all solutions

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