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Chapter 28: Q28-6P (page 951)

From what DNA base sequence was the following RNA sequence transcribed?

(5’) UUCGCAGAGU (3’)

Short Answer

Expert verified

The DNA base sequence from which this RNA sequence is transcribed can be written as (3') AAGCGTCTCA (5').

Step by step solution

01

Given Information

The DNA base sequence can be given as (5’) UUCGCAGAGU (3’).

02

Sense and antisense strand

The antisense strand can be given as,

(3') AAGCGTCTCA (5')

The sense and original DNA strand can be given as,

(5') TTCGCAGAGT (3')

The DNA base sequence from the given RNA transcribed can be denoted as,

(3') AAGCGTCTCA (5')

The base sequence of RNA has U can be replaced with T of the DNA base strand.

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Most popular questions from this chapter

Question: Which of the following base sequences would most likely be recognized by a restriction endonuclease? Explain

  1. GAATTC
  2. GATTACA
  3. CTCGAG

Question: Give an mRNA sequence that will code for the synthesis of mentenkephalin.

Tyr-Gly-Gly-Phe-Met

Question: From what DNA sequences were each of the mRNA codons in problem 28-26 transcribed?

  1. AAU
  2. GAG
  3. UCC
  4. CAU

List codon sequences for the following amino acids:

(a) Ala

(b) Phe

(c) Leu

(d) Tyr

28-38 Valganciclovir, marketed as Valcyte, is an antiviral agent used for the treatment of cytomegalovirus. Called a prodrug, valganciclovir is inactive by itself but is rapidly converted in the intestine by hydrolysis of its ester bond to produce an active drug, called ganciclovir, along with an amino acid.

  1. What amino acid is produced by hydrolysis of the ester bond in valganciclovir?
  2. What is the structure of ganciclovir?
  3. What atoms present in the nucleotide deoxyguanine are missing from ganciclovir?
  4. What role do the atoms missing from deoxyguanine play in DNA replication?
  5. How might valganciclovir interfere with DNA synthesis?
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