Log out Go to App
Go to App

Learning Materials

Features

Discover

Chapter 23: Q37E (page 783)

The amino acid leucine is biosynthesized from α-ketoisovalerate by the following sequence of steps. Show the mechanism of each.

Short Answer

Expert verified

The synthesis of leucine takes place from α-ketoisovalerate.

Step by step solution

01

Given sequence

The given reaction sequence is as follows,

02

Mechanism

Following are the steps involved in the process of synthesis of Leucine is,

  1. Aldol type reaction.
  2. Oxidation of alcohol with help of NAD+
  3. Decarboxylation
  4. Condensation with NH3 followed by reducing the desired product.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Start your free trial

Over 30 million students worldwide already upgrade their learning with Vaia!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

How could you prepare the following cyclohexanones by combining a Stork enamine reaction with an intramolecular aldol condensation? (See Problem 23-64.)

The first step in the citric acid cycle of food metabolism is reaction of oxaloacetate with acetyl CoA to give citrate. Propose a mechanism, using acid or base catalysis as needed.

Show the products you would expect to obtain by Claisen condensation of the following esters:(a) (CH3)2CHCH2CO2Et (b) Ethyl phenylacetate (c) Ethyl cyclohexyl acetate

How might you synthesize each of the following compounds using an aldol reaction? Show the structure of the starting aldehyde(s) or ketone(s) you would use in each case.

The major product formed by intramolecular aldol cyclization of 2,5-heptanedione (Problem 23-51) has two singlet absorptions in the 1H NMR spectrum, at 1.65 d and 1.90 d, and has no absorptions in the range 3 to 10 d. What is its structure?
See all solutions

Recommended explanations on Chemistry Textbooks

Physical Chemistry

Read Explanation

The Earths Atmosphere

Read Explanation

Nuclear Chemistry

Read Explanation

Ionic and Molecular Compounds

Read Explanation

Chemical Analysis

Read Explanation

Making Measurements

Read Explanation
View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.

Sign-up for free