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Chapter 11: 38E (page 350)

Propose a mechanism for the following reaction, an important step in the laboratory synthesis of proteins:

Short Answer

Expert verified

E1 reaction is a substitution nucleophilic unimolecular reaction. It follows first-order kinetics with respect to the substrate.

In the E1 reaction, the deprotonation of hydrogen occurs leading to the formation of carbocation which forms the alkene.

Step by step solution

01

E1 reaction

E1 reaction is a substitution nucleophilic unimolecular reaction. It follows first-order kinetics with respect to the substrate.

In the E1 reaction, the deprotonation of hydrogen occurs leading to the formation of carbocation which forms the alkene.

02

Trifluoroacetic acid

Trifluoroacetic acidic is used as a reagent for the formation of arginine the reagent is used for the deprotonation of the t-BOC group which is used for the protection of the amine group.

03

Mechanism 

  1. Protonation occurs
  2. Leaving group is eliminated
  3. Removal of proton

Mechanism

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