Chapter 1: Problem 1

Define the following terms. a. Lead compound b. High-throughput screen c. Fragment-based screening d. Metabolite e. Transporter f. Enzyme g. Absorption

Short Answer

Expert verified

Lead Compound is a potential drug, High-Throughput Screen identifies active compounds, Fragment-Based Screening finds lead compounds, a Metabolite is a substance produced during metabolism, a Transporter moves molecules across cell membranes, an Enzyme speeds up reactions, and Absorption is the process by which substances are taken into the body's circulation.

Step by step solution

Define Lead Compound

A Lead Compound in medicinal chemistry is a chemical compound that has the potential to be developed into a pharmaceutical drug. It exhibits pharmacological properties that influence biological functions and has the potential to treat diseases.

Define High-Throughput Screen

High-Throughput Screening (HTS) is a method used in drug discovery to identify active compounds, antibodies, or genes which modulate a particular biomolecular pathway.

Define Fragment-Based Screening

Fragment-Based Screening is a method used to discover lead compounds. It involves identifying small chemical fragments, which may bind only weakly to the biological target, and then combining or growing them to produce a lead compound with a stronger binding affinity.

Define Metabolite

A Metabolite is a substance produced during metabolism. It can refer to the substrates, intermediates, and products of metabolic reactions.

Define Transporter

In Biochemistry, a Transporter is a protein that serves as a channel or carrier to facilitate the movement of specific types of molecules across the cell membranes.

Define Enzyme

An Enzyme is a protein molecule that acts as a biological catalyst to speed up the rate of reaction without being consumed or altered.

Define Absorption

Absorption, in the context of biochemistry and pharmacology, refers to the process by which a substance, such as a drug, is taken into the body and moves from the site of administration into the body's circulation system.

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Define the following terms. a. Lead compound b. High-throughput screen c. Fragment-based screening d. Metabolite e. Transporter f. Enzyme g. Absorption

Short Answer

Step by step solution

Define Lead Compound

Define High-Throughput Screen

Define Fragment-Based Screening

Define Metabolite

Define Transporter

Define Enzyme

Define Absorption

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