Chapter 1: Problem 5

What problems are associated with compounds that have low potency for their target?

Short Answer

Expert verified

Compounds with low potency for their target could lead to an increased likelihood of adverse effects, a narrow therapeutic index, cost-effectiveness challenges, and problems with patient compliance.

Step by step solution

Understanding Potency

Potency is the measure of the ability of a compound to interact with its target, typically a protein, and induce a physiological response. A compound is considered to have low potency if a large quantity of it is needed to observe a therapeutic effect.

Problems with Low Potency Compounds

Compounds with low potency for their target can be associated with several problems:1. Increased likelihood of adverse effects: High doses needed for low potency compounds may increase the potential for adverse effects. 2. Therapeutic index: compounds with low potency have a narrow therapeutic index, which is the difference between the effective dose and the toxic dose. 3. Cost-effectiveness: The larger amount of compound needed to achieve therapeutic effect translates to higher costs. 4. Patient compliance: Patients may be less likely to adhere to a treatment regimen if it requires the administration of large quantities of the compound.

Final Summary

In summary, understanding the potency of a compound is critical in drug development, as it helps in quantifying the drug's effectiveness and safety profile. A low potency compound could present additional challenges, including but not limited to: potential for increased adverse effects, a narrow therapeutic index, cost-effectiveness issues, and patient compliance.

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What problems are associated with compounds that have low potency for their target?

Short Answer

Step by step solution

Understanding Potency

Problems with Low Potency Compounds

Final Summary

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