Chapter 2: Problem 4
Consider the earlier days, when drug screening was often done in whole animals, vs. today's more modern methods of drug discovery that often start with a highthroughput screening assay. Which of the following factors do you think are most influential in driving the change toward modern methods? a. Amount of compound needed for the first test. b. Expense of animals needed for the first test. c. Early information on in vivo pharmacokinetic properties. d. Ability to have a direct indication of pharmacodynamic properties.