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Chapter 3: Problem 3

Draw a dose-response curve for: a. a full agonist b. a mixture of a full agonist and a competitive antagonist

Short Answer

Expert verified
In a dose-response curve, a full agonist is shown as an 'S' shaped curve going from the bottom left to top right. A full agonist mixed with a competitive antagonist is also shown as an 'S' shaped curve, but it is displaced to the right on the X-axis, indicating the need for a higher dose of the agonist to achieve the same effect.

Step by step solution

01

Drawing the dose-response curve for a full agonist

On the Y-axis, you will plot the response, which is usually displayed as a percentage of a maximum response. On the X-axis, you plot the dose, usually in increasing concentrations. The graph begins at the origin and increases steeply as the dose of the drug increases. It then plateaus as it reaches near the maximum response, making it look like an 'S' shape.
02

Drawing the dose-response curve for a full agonist mixed with a competitive antagonist

If a competitive antagonist is added to a full agonist, it competes with the agonist for the receptor. This shifts the dose-response curve to the right, indicating that a higher dose of the agonist is needed to achieve the same response. The shape of the curve remains the same 'S' shape, but it is now displaced to the right on the X-axis.

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