You are an ontology consultant and have to advise the clients on ontology
development for the following scenario. What would your advice be, assuming
there are sufficient resources to realize it? Consider topics such as
language, reasoning services, bottom-up, top-down, methods/methodologies. *
A pharmaceutical company is in the process of developing a drug to
treat blood infections. There are about 100 candidate-chemicals in
stock, categorised according to the BigPharmaChemicalsThesaurus, and
they need to find out whether it meets their specification of the ‘ideal’
drug, codename DruTopiate, that has the required features to treat that
disease (they already know that DruTopiate must have as part a benzene
ring, must be water-soluble, smaller than 1 µm, etc). Instead of finding
out by trial-and-error and test all 100 chemicals in the lab in costly
experiments, they want to filter out candidate chemicals by automatic
classification according to those DruTopiate features, and then experiment
only with the few that match the desired properties. This in silico
(on-the-computer) biomedical research is intended as a pilot study, and
it is hoped that the successes obtained in related works, such as that of the
protein phosphatases and ideal rubber molecules, can be achieved
also in this case.